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Analysis of intracellular proapoptotic (Bax, Bak) and antiapoptotic (Bcl-2, Bcl-XL) proteins expression in thyrocytes from young patients with immune and non-immune thyroid disorders --- Analiza ekspresji wewnątrzkomórkowych proapoptotycznych (Bax, Bak) i antyapoptotycznych (Bcl-2, Bcl-XL) białek w tyreocytach u młodocianych pacjentów ze schorzeniami immunologicznymi i nieimmunologicznymi gruczołu tarczowego

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Author(s): Jacek Dadan | Marek Niedziela | Mirosława Urban | Krzysztof Bardadin | Barbara Czarnocka | Artur Bossowski

Journal: Pediatric Endocrinology, Diabetes and Metabolism
ISSN 1234-625X

Volume: 13;
Issue: 2;
Start page: 63;
Date: 2007;
Original page

ABSTRACT
Apoptosis one of the form of programmed cell death is a physiological occurrence, requisite to the correct function of every organism. This is an active process that proceeds with a participation of the cellular metabolism embracing the activation of genes and the synthesis of proteins. The signal to apoptosis can be started practically in every cell of our organism. Disturbances of the apoptosis regulation determine the essential link of the pathogenesis of many diseases, including autoimmune thyroid disorders.The aim of this study was to estimate the expression of proapoptotic (Bax, Bak) and antiapoptotic (Bcl-2, Bcl-XL) proteins in thyroid tissues from 12 patients with Graves' disease (GD), 10 with non-toxic nodular goitre (NTNG) and 10 with toxic nodular goitre (TNG). Criteria for qualification of Graves' patients: large goitre, ophthalmopathy, TRAb > 5 U/L, positive titre of anti-TPO and anti-TG antibodies and concentration of TSH
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