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Analysis of pro-arrhythmic effects induced by different routes of administration of bone marrow stem cells

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Author(s): Anna Vittoria Mattioli | Roberto Lonardi | Enrico Giuliani | Alberto Barbieri | Sonia Pennella | Alberto Farinetti

Journal: Stem Cell Studies
ISSN 2038-9558

Volume: 2;
Issue: 1;
Start page: e1;
Date: 2012;
Original page

Keywords: bone marrow stem cells | intramyocardial injections | ischemia/reperfusion | pre-clinical study | QT interval.

ABSTRACT
There has been repeated concern that intramyocardial (i.m.) delivery of cells could cause ventricular arrhythmias. The aim of the study was to evaluate the pro-arrhythmic effects of bone marrow stem cell (BMSC) injection and compare different routes of administration. An ischemia reperfusion injury was induced in New Zealand rabbits by temporal ligation of anterior descending coronary artery. Homologous BMSCs were isolated, cultured and re-suspended for injection. We compared different routes of BMSC injections, intramyocardial (i.m.) versus intravenous (i.v.) administration of cells. A control group was treated with i.m. injections of saline. The hourly number of supra- and ventricular premature contractions (VPCs), QT interval time and QTc time were recorded and calculated. At Day 7 after cell injections, VPCs were more frequent in the groups treated with i.m. BMSCs and i.m. saline compared with i.v. BMSCs (132 ±19; 54±14 and 34±9, respectively; P
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