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Anatomy and neuro-pathophysiology of the cough reflex arc

Author(s): Polverino Mario | Polverino Francesca | Fasolino Marco | Andò Filippo | Alfieri Antonio | De Blasio Francesco

Journal: Multidisciplinary Respiratory Medicine
ISSN 2049-6958

Volume: 7;
Issue: 1;
Start page: 5;
Date: 2012;
Original page

Keywords: Cough | C-Fibers | Rapidly adapting receptors | Reflex arc | Slowly adapting stretch receptors

Abstract Coughing is an important defensive reflex that occurs through the stimulation of a complex reflex arc. It accounts for a significant number of consultations both at the level of general practitioner and of respiratory specialists. In this review we first analyze the cough reflex under normal conditions; then we analyze the anatomy and the neuro-pathophysiology of the cough reflex arc. The aim of this review is to provide the anatomic and pathophysiologic elements of evaluation of the complex and multiple etiologies of cough.

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