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Anti-convulsant Activity of Hydroalcoholic Extract of Lawsonia Innermis Leaves in Mice

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Author(s): Kabra M.P. | Desai N.V. | Borate S.R. | Rachhadiya R.M. | Shete R.V. | Shobhit Sharma

Journal: International Journal of Pharmaceutical and Phytopharmacological Research
ISSN 2250-1029

Volume: 2;
Issue: 1;
Start page: 7;
Date: 2011;
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Keywords: Anticonvulsant | Lawsonia innermis | PTZ | INH | Epilepsy | Seizures.

ABSTRACT
Epilepsy is a disorder characterized by recurrent seizures of cerebral origin, presenting with episodes of sensory, motor or autonomic phenomenon with or without loss of consciousness. In the present study, anticonvulsant activity of Hydroalcoholic extract of Lawsonia innermis (HAELI) leaves was evaluated against Pentylenetetrazol (PTZ) and Isoniazid (INH) induced convulsions in Swiss Albino Mice. The parameters such as onset of convulsion, Straub tail, Extension of hind limb (EOHL) and occurrence of death was determined. The extract showed protective effect in PTZ and INH induced convulsions. In conclusion, the results of HAELI leaves show anticonvulsant effect in both PTZ and INH induced convulsion models and hence suggesting their possible depressant action in the central nervous system.

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