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Anti-hyperlipidemic activity of the aqueous extract of the Artocarpus heterophyllus leaves in triton WR-1339 induced hyperlipidemic rats.

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Author(s): Venkateswarulu .M**, Prashanthi.K*,Gopi chand Chinta*, Sujata .D, Pushpa kumari.B, Ranganayakulu.D,

Journal: Drug Invention Today
ISSN 0975-7619

Volume: 2;
Issue: 1;
Start page: 25;
Date: 2010;
Original page

Keywords: Artocarpus heterophyllus | Triton WR – 1339 | Serum lipid parameters | Atherogenic index (AI) | Total proteins | Atorvastatin.

ABSTRACT
Experimental evidences are suggesting that the plasma hypercholestrelomic state is a main contributor of the development of cardiovascular diseases like atherosclerosis.The present study an aqueous extract from Artocarpus heterophyllus leaves was designed to evaluated for its hypocholesterolaemic and hypotriglyceridemic activities. Artocarpus heterophyllus leaf extract has not shown any side effects during acute toxicity studies Hyperlipidaemia was developed by intraperitoneal injection of Triton WR – 1339 400mg/kg.The animals were divided into Normal (CG), Triton treated group (T), Triton plus Atorvastatin, Triton plus herb extract 200 mg/kg, Triton plus herb extract 400 mg/kg, treated groups. Oral administration of Artocarpus heterophyllus leaf extract (200 mg/kg and 400 mg/kg) in both groups At 24 hrs after treatment with TRITON WR 1339 caused a significant decrease in serum lipid parameters like Triglycerides (TG), Cholesterol (CH), LDL- cholesterol, Atherogenic index (AI), LDL/HDL Ratio and Total proteins as like in atorvastatin treated groups. The both extract treated groups and atorvastatin treated group bought about a significant increase in HDL-Cholesterol levels levels. Significant reduction in lipid parameters indicates that this herb may contain products that lowers the Serum lipid concentrations and might be beneficial in treatment of hyperlipidaemia.
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