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Anti-inflammatory and anti-pyretic effects of Hibiscus rostellatus Guill. and Perr

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Author(s): Sokeng S.D. 1, *, S.N. Sonhaffouo1 , J. Koube1 , Y.N.L. Nkono 2 , F. Dongmo1 , P. Kamtchouing

Journal: Phytopharmacology
ISSN 2046-1194

Volume: 4;
Issue: 2;
Start page: 434;
Date: 2013;
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Keywords: Hibiscus rostellatus | Anti-inflammatory | Antipyretic | carrageenan-induced paw edema | xylene-induced edema | cotton pellets granuloma.

ABSTRACT
The present study was carried out to evaluate the anti-inflammatory and antipyretic properties of the aqueous leaf extract of H. rostellatus. Carrageenan-induced hind paw edema in rats, xylene-induced ear oedema in mice and cotton pellet-induced granuloma formation in rats were used to investigate anti-inflammatory activity, and brewer’s yeast-induced pyrexia in mice was used to determine antipyretic effect. Oral administration of the plant extract (50 and 100 mg/kg) exhibited a significant (p

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