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Anti-oxidant activity of the aqueous extract of the Morinda citrifolia leaves in triton WR-1339 induced hyperlipidemic rats.

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Author(s): Gopi Chinta*, Venkateswarulu Mullinti, Prashanthi. K, Sujata . D,, Pushpa B, Ranganayakulu. D

Journal: Drug Invention Today
ISSN 0975-7619

Volume: 2;
Issue: 1;
Start page: 1;
Date: 2010;
Original page

Keywords: Morinda citrifolia | Triton WR–1339 | Superoxide dismutase | Malondialdehyde | Catalase | Reduced glutathione.

ABSTRACT
Different epidemiological studies have shown that the oxidative stress is one of the major contributor of the development of hyperlipidemia and atherosclerosis. This study was aimed to evaluate the antioxidant activity of aqueous extract from Morinda citrifolia leaves against hyperlipidemic rats. Morinda citrifolia leaf extract has not shown any side effects during acute toxicity studies Hyperlipidemia was developed by intraperitoneal injection of Triton WR – 1339 400mg/kg.The animals were divided into Normal group, Triton treated group (T), Triton plus Atorvastatin, Triton plus herb extract 150 mg/kg, Triton plus herb extract 300 mg/kg, treated groups. Oral administration of Morinda citrifolia leaf extract (150 mg/kg and 300 mg/kg) in both groups At 24 hrs after treatment with TRITON WR 1339 caused a significant decrease in Malondialdehyde levels and significant increase in Superoxide dismutase (SOD), Reduced glutathione, Catalase levels as like in atorvastatin treated groups. Significant reduction in above stated anti-oxidant parameters indicating that this herb may contain products that lowers the oxidative stress and might be beneficial in treatment of hyperlipidemia.
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