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Anti-oxidant activity of the Butea monosperma leaves alone and in combination with Atorvastatin

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Author(s): *Sai Krishna.N,Ranganayakulu .D, Sujatha .D*, Pushpa kumari .B, Venkateswarulu.M, GopiChandChinta*

Journal: Drug Invention Today
ISSN 0975-7619

Volume: 2;
Issue: 2;
Start page: 149;
Date: 2010;
Original page

Keywords: Oxidative stress. Butea monosperma | High fat diet | Atherosclerosis | Atorvastatin

ABSTRACT
Oxidative stress which is considering as one of the most major contributor for the development of atherosclerosis. In the present study we have assessed the antioxidant effect of the ethanolic extract of leves of the Butea monosperma as alone and in combination with the atorvastatin in high fat diet induced atheroscleroteic rats. Test drug extract wasn’t exhibit any side effects during the acute toxicity studies. The animals were divided into Normal group, High fat diet group (HFD),High fat diet plus atorvastatin 5mg/kg, High fat diet + Butea monosperma leaf extract 400mg/kg i.p, High fat diet + atorvastatin 5mg/kg + Butea monosperma leaf extract 200mg/kg i.p, treated groups. Administration of the Butea monosperma leaf extract alone and in combination with Atorvastatin significantly increased the Superoxide dismutase (SOD), Catalase (CAT), reduced glutathione (GSH) along with a reduction in Malondialdehyde (MDA) after the 28 days treatment. Significant beneficial effects produced in all the above parameters in all the above parameters is indicting that leaves of this plant is may contain the components that may be effective in treatment of oxidative stress involved in hyperlipidemia and atherosclerosis.
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