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ANTI UROLITHIATIC ACTIVITY OF MACROTYLOMA UNIFLORUM SEED EXTRACT ON ETHYLENE GLYCOL INDUCED UROLITHIASIS IN ALBINO RATS

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Author(s): D. Anantha Krishna Chaitanya, | M. Santosh kumar, | A. Manohar Reddy, | N.S.V. Mukherjee, | M.H. Sumanth, | DR. A. Ramesh

Journal: Journal of Innovative Trends in Pharmaceutical Sciences
ISSN 0975-8593

Volume: 1;
Issue: 5;
Start page: 216;
Date: 2010;
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Keywords: Ethylene glycol | seeds | Hyperoxaluria | Macrotyloma uniflorum | Urolithiasis.

ABSTRACT
The effect of oral administration of aqueous and alcohol extracts of Macrotyloma uniflorum (Fabaceae) seeds on calcium oxalate urolithiasis has been studied in male albino wistar rats.Ethylene glycol feeding resulted in hyperoxaluria as well as increased renal excretion of calcium and phosphate. Supplementation with aqueous and alcohol extract of Macrotylomauniflorum seeds significantly reduced the elevated urinary oxalate showing a regulatory action on endogenous oxalate synthesis. The increased deposition of stone forming constituents in the kidneys of calculogenic rats was significantly lowered by curative andpreventive treatment using aqueous and alcohol extracts. The results indicate that the seeds of M. uniflorum are endowed with significant antiurolithiatic activity and it also indicate that the alcoholic extract of M.uniflorum shows better anti urolithiatic activity than aqueous extract.

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