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Antioxidant Activity of Ethanolic Extract of Aerial parts of Piper trioicum Roxb.

Author(s): Aparna Lakshmi I*1, Gobinath M1, Madhusudan T 1, Praveen kumar D 1, Suresh kumar Reddy A 1, Saraswathi L 1, Geetha C 1, Chandana I 1

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 9;
Start page: 2894;
Date: 2011;
Original page

Keywords: Piper trioicum | antioxidant | in vitro | reducing power

The present study was sought to investigate the antioxidant potential of ethanolic extract of aerial parts of Piper trioicum Roxb (EEPT). The ethanolicextract of aerial parts of Piper trioicum was prepared and phytochemical screening was performed to identify the plant constituents. The antioxidant activitywas evaluated by measuring Total flavanoid content, Total Phenolic content and by various in vitro methods like DPPH assay, Nitric oxide scavenging activity,H2O2 scavenging activity, Reducing power of the extract, Total antioxidant status. The preliminary phytochemical screening of the ethanolic extract of Pipertrioicum Roxb showed the presence of flavanoids, alkaloids, tannins, carbohydrates, phenols and proteins. The total flavanoid content and phenolic contentwere found to be 23.87% and 34.23 mg gallic acid equivalent /g extract respectively. The IC50 value of the extract from the DP PH assay was found to be 77.25μg/ml. The scavenging activity of EEPT on various free radical assays like Nitric oxide scavenging activity, H2O2 scavenging activity, Reducing power of theextract in various concentrations was found to be dose dependent. Serum TAR (Total antioxidant response) of EEPT found to be (0.054 mmol Trolox equiv./l). From the obtained results it can be concluded that the ethanolic extract of Piper trioicum has good antioxidant property and could be explored as a naturalantioxidant.
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