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Antioxidant and Apoptotic Effects of Caffeic Acid Phenethyl Ester Induced Marked Inhibition on Human Breast Cancer Cell Line

Author(s): Mohamed F. El-Refaei | Mona M. El-Naa

Journal: Asian Journal of Biochemistry
ISSN 1815-9923

Volume: 6;
Issue: 1;
Start page: 82;
Date: 2011;
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Keywords: Anti-tumor | antioxidant enzymes | anti-proliferative | apoptosis

in vitro by our assessment of a ZR-75-1 human breast cancer cell line. Present data showed that 15 M CAPE induced a significant inhibition of cell viability after 48 h (nearly 50%). Cell death was characterized by morphology and chromatin condensation changes, of a typical apoptosis. Moreover, there was a scavenging reduction activity in vitro towards both nitric oxide (>47%) and superoxide dismutase reduction (169.33.7 U L-1). In addition, malondialdehyde was non significantly inhibited compared with untreated tumor cells. The CAPE has significant inhibitory and anti-proliferative effects on tumor cancer cells in vitro. This inhibition may be related to its antioxidant effects and achieved throughout its apoptotic effect. These findings provide the possibility for the future use of CAPE in human clinical trials therapy.]]>
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