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Antioxidant and Hepatoprotective Potential of Soy Isoflavones Against CCl4 Induced Oxidative Stress and Early Tumor Events

Author(s): Tajdar Husain Khan | Sarawat Sultana

Journal: Indo Global Journal of Pharmaceutical Sciences
ISSN 2249-1023

Volume: 1;
Issue: 1;
Start page: 39;
Date: 2011;
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Keywords: Soy Isoflavones | Antioxidants | CCl4 | Tumor Promotion | ODC

In the present study we have evaluated the hepatoprotective efficacy of soy isoflavones (SIF), against carbon tetrachloride (CCl4) induced oxidative damage and early tumor response in male Wistar rats. Methods: Single treatment of CCl4 (1:1 v/v in corn oil was administered orally at dose of 1ml kg - 1 body weight) induced oxidative stress and enhanced early tumor markers. Results: CCl4treatment resulted in marked reduction of hepatic glutathione content and activities of hepatic anti-oxidant enzymes, viz., glutathione peroxidase (GPx), glutathione reductase (GR), catalase (CAT), glucose-6-phosphate dehydrogenase (G6PD) and phase-II metabolising enzymes such as glutathione-S-transferase (GST) and quinonereductase (QR) significantly as compared to control group (p
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