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Anxiolytic activity of ethanolic extract of leaves of Ocimum sanctum in rats

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Author(s): Sudhakar Pemminati, Swati B, Shreyasi C, Chandrasekhar R, GopalaKrishna HN*,Pai MRSM.

Journal: Drug Invention Today
ISSN 0975-7619

Volume: 2;
Issue: 2;
Start page: 115;
Date: 2010;
Original page

Keywords: Anxiolytic | Ocimum sanctum | Diazepam

ABSTRACT
Anxiety is a normal emotional behaviour. When it is severe and/or chronic, however, it becomes pathological and can precipitate or aggravate cardiovascular and psychiatric disorders. Although many drugs are available in allopathic medicine to treat anxiety disorders, they produce various systemic side effects or exhibit tolerance upon chronic use. Benzodiazepines (BZDs) are the major class of compounds used in anxiety and they remain the most commonly prescribed treatment for anxiety. However BZDs have many unwanted side effects that prompted many researchers to evaluate new compounds in the hope of identifying other anxiolytics with fewer side effects. In the present study, we have attempted to evaluate the anxiolytic-like activity of ethanolic extract of leaves of Ocimum sanctum(OS) in rats by employing the two pharmacologically validated models, elevated plus maze and bright and dark arena. The rats were divided into five groups, each group containing six animals. The effects of the test drug OS (at 1.75, 4.25 and 8.5 mg/kg doses), the standard anxiolytic, diazepam (1.0 mg/kg) and control group 1%gum acacia(10ml/kg) were assessed after single and repeated dose administration for ten days. The results suggest that, behavioural disinhibitory effects of OS exhibited anxiolytic like activity comparable to diazepam.
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