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Aqueous Microwave-Assisted Solid-Phase Synthesis Using Boc-Amino Acid Nanoparticles

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Author(s): Keiko Hojo | Natsuki Shinozaki | Yoshimi Nozawa | Yoshinobu Fukumori | Hideki Ichikawa

Journal: Applied Sciences
ISSN 2076-3417

Volume: 3;
Issue: 3;
Start page: 614;
Date: 2013;
Original page

Keywords: aqueous synthesis | solid-phase peptide synthesis | microwave assisted synthesis | nanoparticles | Boc chemistry

ABSTRACT
We have previously developed water-based microwave (MW)-assisted peptide synthesis using Fmoc-amino acid nanopaticles. It is an organic solvent-free, environmentally friendly method for peptide synthesis. Here we describe water-based MW-assisted solid-phase synthesis using Boc-amino acid nanoparticles. The microwave irradiation allowed rapid solid-phase reaction of nanoparticle reactants on the resin in water. We also demonstrated the syntheses of Leu-enkephalin, Tyr-Gly-Gly-Phe-Leu-OH, and difficult sequence model peptide, Val-Ala-Val-Ala-Gly-OH, using our water-based MW-assisted protocol with Boc-amino acid nanoparticles.
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