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Association between Cardiovascular Fitness and Inflammatory Markers in Boys Aged 11-14 Years

Author(s): Abbas-Ali Gaeini | Ali-Asghar Fallahi | Abdolreza Abdolreza Kazemi | Ramin Kordi

Journal: Iranian Journal of Pediatrics
ISSN 2008-2142

Volume: 19;
Issue: 3;
Start page: 262;
Date: 2009;
Original page

Keywords: Inflammatory markers | VO2 max | Children | Obesity | C- Reactive protein | Interleukin-6

Objective: It is reported that some inflammatory markers are predictive factors for atherosclerosis in childhood and adolescence and cardiovascular disease in adulthood. We investigated whether markers of inflammation including: cytokine [Interleukin-6 (IL-6)], acute-phase reactant [C-reactive protein (CRP)], white blood cell (WBC) count and its subgroups are associated with maximal oxygen consumption (VO2max) in overweight and normal children. Methods: Subjects were 26 boys aged 11-14 years included in two groups of overweight (n=10) and normal weight (n=16) children. VO2max was measured employing an incremental graded exercise test. IL-6 and CRP levels as well as WBC count were measured. Multivariable regression was employed to evaluate whether inflammatory markers were associated with VO2max. Findings: Mean VO2max for all subjects (n=26) was 36.35±10.42 ml/kg/min. This rate was lesser for overweight subjects (25.77±5.04) than in normal weight children (41.54±5.96). Log IL-6, log CRP, and WBC count were correlated with VO2max. Also subgroups of WBC including Leukocytes, Lymphocyte, Neutrophils, Monocytes and Eosinophils associated with VO2max. Conclusion: IL-6, CRP and WBCs were inversely associated with aerobic or cardiorespiratory fitness levels measured by VO2max in children. This was independent of BMI of the subjects.
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