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Asymmetric Reductive Amination of Carbonyl Compounds by Using N,N,N-Tributylpropanaminium Based Novel Chiral Ionic Liquid

Author(s): Boyina Rupini | Sharda Pasricha | Brijesh Rathi

Journal: International Journal of Organic Chemistry
ISSN 2161-4687

Volume: 03;
Issue: 03;
Start page: 190;
Date: 2013;
Original page

Keywords: Ionic Liquid | Asymmetric Reductive Amination | Chiral | Carbonyl Compounds

Asymmetric reductive amination of carbonyl compounds was carried out using a novel class of aliphatic quarternary ammonium based chiral ionic liquid. S-(+)-2,3-dihydroxy-N,N,N-tributylpropanaminum bromide chiral ionic liquid has been synthesized, characterized and used for asymmetric reductive amination of carbonyl compounds in the presence of sodium borohydride. These preliminary results are encouraging and advocate dual role of novel ionic liquid as a medium and reducing agent for proficient conversion of ketones to amines, however, reductive amination reaction needs to be established for other substituents.
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