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Biocidal activity of metalloacid-coated surfaces against multidrug-resistant microorganisms

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Author(s): Tétault Nathalie | Gbaguidi-Haore Houssein | Bertrand Xavier | Quentin Roland | van der Mee-Marquet Nathalie

Journal: Antimicrobial Resistance and Infection Control
ISSN 2047-2994

Volume: 1;
Issue: 1;
Start page: 35;
Date: 2012;
Original page

Keywords: Metalloacid-coated surface | Biocidal effect | Infection control

ABSTRACT
Abstract Background The antimicrobial effects of a coating of molybdenum trioxide (MoO3) has been recently described. The metalloacid material produces oxonium ions (H3O+), which creates an acidic pH that is an effective, non specific antimicrobial. We determined the in vitro antimicrobial activity of molybdenum trioxide metalloacid-coated surfaces. Methods Metalloacid-coated and non-coated (control) surfaces were contaminated by exposing them for 15 minutes to microbial suspensions containing 105 cfu/mL. Eleven microorganisms responsible for nosocomial infections were tested: two Staphylococcus aureus strains (the hetero-vancomycin intermediate MRSA Mu50 strain and a ST80-PVL-producing MRSA strain); a vancomycin-resistant vanA Enterococcus faecium strain; three extended-spectrum beta-lactamase-producing Enterobacteriaceae strains; a MBL-producing Pseudomonas aeruginosa strain; a multidrug-resistant Acinetobacter baumannii strain; a toxin-producing Clostridium difficile strain; and two fungi (Candida albicans and Aspergillus fumigatus). The assay tested the ability of the coated surfaces to kill microorganisms. Results Against all non-sporulating microorganisms tested, metalloacid-coated surfaces exhibited significant antimicrobial activity relative to that of the control surfaces within two to six hours after contact with the microorganisms (p 
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