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BIOLOGICAL ACTIVITY OF NEWLY SYNTHESIZED M(II) HETEROCHELATES OF COUMARIN DERIVATIVE AND ENROFLOXACIN Biologische Aktivit├Ąt des neu synthetisierten M (II) HETEROCHELATES Von Cumarin-Derivat und ENROFLOXACIN

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Author(s): Ketan S.Patel1, Ravi B Patel1 and Rajarshi N Patel

Journal: Heterocyclic Letters
ISSN 2231-3087

Volume: 3;
Issue: 4;
Start page: 493;
Date: 2013;
Original page

Keywords: Heterochelates | enrofloxacin | biological aspect

ABSTRACT
Some novel heterochelates synthesized by reflux of 6-bromo-3-(3-(4-chlorophenyl)acryloyl)-2Hchromen- 2-one, enrofloxacin and various transition metal. 1H, 13C, IR and ESI Mass confirm the formation of ligand. The heterochelates were characterized on the basis of different spectroscopic techniques like IR studies and elemental analysis while the geometry of complexes was octahedral which is confirmed by electronic spectra and thermogravimetric analysis. The compounds were subjected to antimicrobial, antioxidant and anti-tubercular activity viewing using serial broth dilution method and Minimum Inhibitory Concentration (MIC) is determined. Mn(II) complex has shown significant antifungal activity with an MIC of 6.250g/mL while Cu(II) complex is perceptible for antibacterial activity at the same concentration. Anti-TB activity of the ligand has superior on complexation with Ni(II) and Co(II) ions. While Ni(II) complex shows finer antioxidant activity than other complexes.
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