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Biological Significances, Diagnostic Values and Therapeutic Approach of Proinsulin Connecting Peptide

Author(s): Gamal El-din I. Harisa

Journal: Asian Journal of Biochemistry
ISSN 1815-9923

Volume: 6;
Issue: 3;
Start page: 214;
Date: 2011;
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Keywords: signal transduction | Proinsulin | insulin | C-peptide

2+ and diacylglycerol (DAG) leading to activation of many cellular signaling. The treatment of diabetic patients in particular type 2 with C-peptide resulted in improved glucose metabolism as well as blood flow. So that renal functions in addition to nerve functions are get well again. C-peptide and insulin are secreted in equimolar amounts; therefore the measurement of C-peptide permits the quantitation of insulin secretion. Due to the longer half life of C-peptide than insulin it regard as a god indicator for endogenous insulin secretion. C-peptide is sensitive to physiological degradation therefore, several strategies are taken to improve the bioavailability for C-peptide. These strategies include amino acids modification, endogenous carrier conjugation, liposome incorporation and peptidase inhibition. These data indicated that C-peptide is biologically active peptide and has many functions in treatment of diabetic associated complications. Further, studies in particular in vivo are required to explore the exact roles of C-peptide the treatment of diabetic associated complications as well as cardiovascular disease.]]>
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