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Caloric restriction and its mimetics

Author(s): Shin-Hae Lee | Kyung-Jin Min

Journal: BMB Reports
ISSN 1976-6696

Volume: 46;
Issue: 4;
Start page: 181;
Date: 2013;
Original page

Keywords: Caloric restriction | CR mimetics | Lifespan extension | Longevity

Caloric restriction is the most reliable intervention to preventage-related disorders and extend lifespan. The reduction ofcalories by 10-30% compared to an ad libitum diet is known toextend the longevity of various species from yeast to rodents.The underlying mechanisms by which the benefits of caloricrestriction occur have not yet been clearly defined. However,many studies are being conducted in an attempt to elucidatethese mechanisms, and there are indications that the benefits ofcaloric restriction are related to alteration of the metabolic rateand the accumulation of reactive oxygen species. Duringmolecular signaling, insulin/insulin-like growth factor signaling,target of rapamycin pathway, adenosine monophosphateactivated protein kinase signaling, and Sirtuin are focused asunderlying pathways that mediate the benefits of caloricrestriction. Here, we will review the current status of caloricrestriction. [BMB Reports 2013; 46(4): 181-187]

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