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A Candidate SNP in the Bovine SP110 Gene is not Associated with Susceptibility to Tuberculosis in Cattle

Author(s): O. Ruiz-LarraƱaga | C. Manzano | M. Iriondo | J.M. Garrido | M. Aguirre | P. Vazquez | R.A. Juste | A. Estonba

Journal: International Journal of Animal and Veterinary Advances
ISSN 2041-2894

Volume: 3;
Issue: 6;
Start page: 407;
Date: 2011;
Original page

Keywords: Bovine tuberculosis | genetic association | single nucleotide polymorphism | SP110 nuclear body protein

The human SP110 nuclear body protein (SP110) gene and the orthologous murine Intracellular pathogen resistance 1 (Ipr1) have been reported to be related with susceptibility to tuberculosis. In addition, a recent study reported that SNP c.587A>G (N196S) in the bovine SP110 gene is associated with susceptibility to Mycobacterium avium subsp. paratuberculosis infection in dairy cattle. The objective of the present study was to analyze the putative association between SNP c.587A>G in SP110 gene and susceptibility to Mycobacterium bovis infection in cattle. A total of 158 cows (50 infected and 108 non-infected) from a multibreed sample were included in the study. Neither SNP c.587A>G alleles nor genotypes showed significant association with susceptibility to Mycobacterium bovis infection in the analyzed cattle population. Nevertheless, other SNPs in this gene must be analyzed in order to rule out the implication of SP110 gene in susceptibility to bovine tuberculosis.

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