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Caracterización fenotípica de lipoproteínas de baja densidad y su relación con el síndrome metabólico

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Author(s): Milagros Espinoza | Dayana Figueira | Sara Cid | Emilia Barrios | Nelina Ruiz | Ulises Leal | Santina Coccione

Journal: Salus Online
ISSN 1316-7138

Volume: 16;
Issue: 2;
Start page: 64;
Date: 2012;
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Keywords: Phenotype B | metabolic syndrome | cardiovascular risk

ABSTRACT
Currently, there has been a steadilygrowing interest on the risk factors associated with metabolic syndrome (MS), and several studies have shown that the B phenotype is highly atherogenic, since these low density lipoprotein (LDL) particles which have been considered small and dense, have a different spatial distribution from the normal LDL. The aim of this study was to characterize phenotypically LDL particles in adult patients diagnosed with SM, and to relate the latter with its defining factors, taking into account the ATP III consensus. This was a descriptive, cross-sectional intentional study involving 169 patients divided into two groups, 93 patients withMS and 76 without this condition, who had glucose, HDL, triglyceride, and polyacrylamide-gel electrophoresis determinations for phenotypic characterization of LDL. Blood pressure and waist circumference were measured. The age range of the sample was between 20 and 84 years (40.3 ± 14.8); 40.2% of the studied patients were phenotype B and 59.8%, phenotype A. When comparing both groups, significant differences in the variables studied were observed. It is concluded that, compared with individuals who did not meet the criteria for diagnosis, patients with MS had higher oncentrations of phenotype B. Also, there was a significant association between phenotype B and the presence of SM. This association was directly related to serum triglycerides, abdominal obesity and diastolic blood pressure.
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