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Carboplatin-mediated changes in the activity levels of steroidogenic marker enzymes, serum hormones and testicular architecture in male rats.

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Author(s): *Y. Kishore Reddy, P. Reddy, M. Shivalingam, B. Devi, CNNS G, D. Anusha

Journal: Drug Invention Today
ISSN 0975-7619

Volume: 2;
Issue: 1;
Start page: 42;
Date: 2010;
Original page

Keywords: Carboplatin | Steroidogenic marker enzymes | LH | FSH | Testosterone | Testicular architecture | Rats.

ABSTRACT
Carboplatin (10 mg/ kg body weight) caused significant decrease in the activity levels of steroidogenic marker enzymes such as 3â-hydroxy steroid dehydrogenase and 17â-hydroxy steroid dehydrogenase in experimental rats when compared to that of the control rats. In addition, activity levels of serum hormones including LH, FSH and Testosterone were also altered significantly in experimental animals. Besides, causing significant alterations in the activity levels of steroidogenic marker enzymes, and serum hormones, carboplatin treatment also caused changes in testicular architecture in rats.
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