Academic Journals Database
Disseminating quality controlled scientific knowledge

Cardioactive effects of diphenhydramine and curcumin in Daphnia magna

Author(s): Avinash Vaidya | Laura Gurenlian | Lauren Brady | Noelle Erin Romero | Rebecca Kohn

Journal: Impulse : an Undergraduate Journal for Neuroscience
ISSN 1934-3361

Start page: 1;
Date: 2009;
VIEW PDF   PDF DOWNLOAD PDF   Download PDF Original page

Keywords: curcumin | histamine | DPHM | heart rate | H1-histamine receptor | D. magna

Although used as a model for examining the cardioactive effects of various compounds, the neuromuscular regulation of the heart of the crustacean Daphnia magna (D. magna) is not well understood. In the present study, we sought to determine how the heart rate of D. magna was affected by two previously untested compounds: curcumin and diphenhydramine (DPHM). DPHM produces a number of cardiotoxic side effects in vertebrates, particularly sinus tachycardia. Curcumin acts as a monoamine oxidase inhibitor (MAOI) and was expected toincrease the heart rate of D. magna. DPHM was found unexpectedly to lower the heart rate of D. magna with time. Curcumin increased heart rate when administered in higher concentrations. However, co-administration of curcumin with DPHM negated this effect. These findings may be explained by the potential role of histamine as a sympathetic cardiac neurotransmitter in D. magna.

HR software für Hotellerie

Automatische Erstellung
von Personaldokumente
und Anmeldungen bei Behörden


Tango Jona
Tangokurs Rapperswil-Jona