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Cardiovascular autonomic function tests in type 2 diabetes mellitus with micro albuminuria

Author(s): Sudhavana S. | Deepak P.

Journal: Electronic Physician
ISSN 2008-5842

Volume: 4;
Issue: 2;
Start page: 502;
Date: 2012;
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Keywords: Cardiovascular autonomic function | Microalbuminuria | Type2 diabetes

Introduction: Cardiovascular disease is the leading cause of death in type2 diabetes (DM). Microalbuminuria (MA)is strongly associated with cardiovascular complications in type2 diabetes. Impaired cardiovascular autonomicfunction and increased albumin excretion are related in patients with diabetes. So this study is designed toinvestigate the relationship between cardiovascular autonomic function and microalbuminuria in type2 diabetes.Methods: The study comprised of 180 subjects of age group>50 years, classified into 3 groups of 60 subjects each.DM without MA, DM with MA and controls. The tests performed were 1) Heart rate response to deep breathing,valsalva maneuver and standing; 2) Blood pressure response to standing and to sustained handgrip. Individual testswere given score of 0, 1, or 2 and an overall autonomic test score of 0-10 was obtained.Results: Mean autonomic score in control, DM without MA and DM with MA are 1.97 ± 0.81, 5.73 ± 1.26 and 7.00± 1.80 respectively. The Coefficient of variation (%) of control, DM without MA, DM with MA is 41.1, 21.9 and25.7 respectively. A significant difference in autonomic score was observed in the DM without MA (P
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