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A case of small cell carcinoma of the vagina

Author(s): Ryosuke Tamura | Yoshihito Yokoyama | Asami Kabayashi | Yuuki Osawa | Tatsuhiko Shigeto | Masayuki Futagami | Hideki Mizunuma

Journal: Rare Tumors
ISSN 2036-3605

Volume: 5;
Issue: 4;
Start page: e58;
Date: 2013;
Original page

Keywords: small cell carcinoma of the vagina | radiotherapy

Primary small cell carcinoma of the vagina is quite rare, and a standard treatment has not been established yet. Herein, we report a case of an 81-year-old woman who was diagnosed with a vaginal tumor without continuity with the uterine cervix. Histopathological diagnosis indicated alveolar solid growth of nuclear chromatin-rich atypical cells with a high N/C ratio and a partially recognized rosette-like structure, suggesting a differentiated neuroendocrine system. Chromogranin A and synapto- physin were positive. Stage I vaginal small cell carcinoma localized to the vagina was diagnosed. The tumor disappeared by radiation monotherapy with external beam irradiation and endocavitary irradiation. The patient remains alive without any disease 1 year and 8 months after the treatment, suggesting the efficacy of radiotherapy in small cell carcinoma of the vagina.
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