Academic Journals Database
Disseminating quality controlled scientific knowledge

Changes in the T-lymphocytes (CD3+CD19-) and activated Tlymphocytes (CD3+HLA-DR+) in patients over 60 with mediterranean spotted fever

Author(s): Margarita GOSPODINOVA

Journal: European Medical, Health and Pharmaceutical Journal
ISSN 1804-5804

Volume: 2;
Start page: 31;
Date: 2011;
VIEW PDF   PDF DOWNLOAD PDF   Download PDF Original page

Keywords: Elderly | Cell Immunity | Rickettsiosis | Severity

Mediterranean spotted fever (MSF) in Bulgaria shows increasing severity, especially in patients over sixty years. As Tlymphocytes are the primary effector cells in MSF and are altered by the ageing process we aimed to specify the changesin their numbers in elderly patients. We performed a clinicoepidemiological study, haematological and biochemical analysisof 132 patients of 60+ and 30 patients between 19 and 57 years with MSF. We investigated the cell immunity of 20 patientsof 60+ using immunofluocytometry. The control group consisted of 10 younger patients and 10 healthy individuals of 60+.MSF showed more unfavourable course in the elderly.We found T-lymphocytes depletion in all patients with MSF. ActivatedT lymphocytes were increased in elderly patients with MSF. We found significant differences between the number of activated T lymphocytes in elderly patients and healthy elderly persons. The observed T-lymphocytes depletion in MSF corresponded to the disease severity. The increase in the activated T lymphocytes in patients over 60 years contributes to an adequate immune response.
RPA Switzerland

RPA Switzerland

Robotic process automation


Tango Rapperswil
Tango Rapperswil