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Changing Patterns of Antibiotic Resistances of Salmonella enterica Serovar Typhi in Kolkata, India

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Author(s): Shyamapada Mandal | Manisha DebMandal | Nishith Kumar Pal

Journal: Advanced Biotech
ISSN 0973-0109

Volume: 13;
Issue: 02;
Start page: 01;
Date: 2013;
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Keywords: MDR | Salmonella entericaserovar Typhi | antibiotic synergy | ciprofloxacin treatment failure | treatment protocol

ABSTRACT
Enteric fever due to the infection of multidrug-resistant (MDR) Salmonella enterica serovar Typhi, having plasmid mediated resistance to chloramphenicol (C), co-trimoxazole (Co) and ampicillin (A), has posed a serious therapeutic challenge in many parts, including olkata, in India. Ciprofloxacin (Cp) was found to be the antibiotic of choice for MDR typhoid fever. However, Cp treatment failure of enteric fever has been recorded, and among S. Typhi isolates resistance to Nx may be an indicator of decreased susceptibility to Cp. This underlines the importance of ceftriaxone (Ct) for treating MDR and Cp-resistant enteric fever cases; however, the Ct resistance in is known. Finally, the synergistic anti- S. Typhi activity of Cp with other conventional anti-typhoid antibiotics has been established. This review is thus expected to be helpful in the preparation of effective treatment protocol, benefiting peoples of this part of the globe, where enteric fever due to the infection of MDR S. Typhi is a great problem.
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