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Chemical Constituents and Pharmacological Properties of Capsule Gurmar- A New Anti-diabetic Formulation of Hamdard Laboratories (Waqf) Bangladesh

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Author(s): Mirola Afroze | Mridul Kabiraz | Robiul Islam | Abdul Ghani

Journal: Stamford Journal of Pharmaceutical Sciences
ISSN 1999-7108

Volume: 3;
Issue: 1;
Start page: 18;
Date: 2010;
Original page

Keywords: capsule Gurmar | chemical constituents | pharmacological properties | hypoglycemic effects.

ABSTRACT
Capsule Gurmar is a new polyherbal Unani formulation developed by the R&D department of Hamdard Laboratories (Waqf) Bangladesh for management and treatment of diabetes. This study was aimed to investigate the chemical constituents and analgesic, antioxidant, neuropharmacological, cytotoxic, and hypoglycemic properties of the formulation using standard methods. Phytochemical tests on the hydromethanolic extract of the contents of the capsules showed the presence of carbohydrates, glycosides, saponins, steroids, flavonoids, alkaloids and tannins in the formulation. When tested by acetic acid-induced Writhing test, the extract at higher dose (400mg/kg) showed mild analgesic activity compared to standard drug Diclofenac-Na (10mg/kg). But, by Tail immersion method, the extract at the same dose showed moderate analgesic activity compared to the standard drug, Nalbuphine at 10mg/kg body weight. The Gurmar capsule extract exhibited high total antioxidant capacity (622.326 mg/g) and had high flavonoid (386.43 mg/g) and phenol (184.60 mg/g) contents. In the Hole cross and Open field tests, the extract displayed significant suppression of locomotor activity and exploratory behaviour of the mice. When subjected to Brine shrimp Lethality Bioassay, the extract was found to be significantly toxic to Brine shrimp nauplii (having LC50 value of 3.16µg/ml). Glucose Tolerance Test (GTT) demonstrated quite strong hypoglycemic activity of the formulation, which significantly lowered the blood glucose level of the treated mice both at doses of 100 mg and 200mg/kg body weight. The hypoglycemic effect was comparable to that of the standard oral hypoglycemic drug, Metformin hydrochloride at the dose of 100mg/kg. These results indicate that Capsule Gurmar possesses mild analgesic, antioxidant, CNS depressant, cytotoxic, and hypoglycemic properties.
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