Author(s): Vijay V Dabholkar, Navnath Shinde, Abhishek karekar, Prem naik
Journal: Heterocyclic Letters
ISSN 2231-3087
Volume: 3;
Issue: 4;
Start page: 525;
Date: 2013;
Original page
Keywords: Oxadiazole | Biphenyl compound | Dibromo alkane | L- valine methyl ester.
ABSTRACT
2 -Cyano-4-bromomethyl biphenyl (1) was reacted with hydroxylamine hydrochloride in the presences of sodium carbonate to obtain (2) which on further treatment with 2 methyl, 4 amino pyridine yielded (3), compound (2) on condensation with L- valine methyl ester gave (4) which was then further cyclised with aliphatic bromo alkane to yield the respective cyclic 3,5 disubsutited 1,2,4 oxadiazoles.The structures of the synthesized compounds were confirmed by physico-chemical test and spectral techniques, representative samples evaluated for their antimicrobial activity against gram positive and gram negative bacteria.
Journal: Heterocyclic Letters
ISSN 2231-3087
Volume: 3;
Issue: 4;
Start page: 525;
Date: 2013;
Original page
Keywords: Oxadiazole | Biphenyl compound | Dibromo alkane | L- valine methyl ester.
ABSTRACT
2 -Cyano-4-bromomethyl biphenyl (1) was reacted with hydroxylamine hydrochloride in the presences of sodium carbonate to obtain (2) which on further treatment with 2 methyl, 4 amino pyridine yielded (3), compound (2) on condensation with L- valine methyl ester gave (4) which was then further cyclised with aliphatic bromo alkane to yield the respective cyclic 3,5 disubsutited 1,2,4 oxadiazoles.The structures of the synthesized compounds were confirmed by physico-chemical test and spectral techniques, representative samples evaluated for their antimicrobial activity against gram positive and gram negative bacteria.
