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Chronology of Bioactive Glass Development and Clinical Applications

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Author(s): Larry L. Hench

Journal: New Journal of Glass and Ceramics
ISSN 2161-7554

Volume: 03;
Issue: 02;
Start page: 67;
Date: 2013;
Original page

Keywords: Bioactive Glass; 45S5 Bioglass; Hydroxyl-Carbonate Apatite (HCA); Bone-Bonding; Osteogenesis; Regeneration; Genes | Dental; ENT; Maxillo-Facial; Orthopedics; Clinical; Osteostimulation

ABSTRACT
The key research and development steps for bioactive glass (45S5 Bioglass) are documented from the date of discovery in 1969 through FDA approvals of the first dental, ENT, maxillo-facial and orthopedic clinical products. Understanding the mechanisms and quantifying the rapid surface reactions to form a bone-bonding hydroxyl-carbonate apatite (HCA) layer on the bioactive glass in contact with living bone was a vital part of the early development of this class of biomaterials. A key later discovery was enhanced osteogenesis and in situ bone regeneration by controlled release of ionic dissolution products from the bioactive glass particulates that leads to up-regulation and activation of seven families of genes, a process called osteostimulation.
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