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Circulating Tumor Cells: A Potential Bladder Cancer Biomarker?

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Author(s): David J Gallagher | Matthew I Milowsky

Journal: European Journal of Clinical & Medical Oncology
ISSN 1759-8958

Volume: 2;
Issue: 1;
Start page: 105;
Date: 2010;
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Keywords: bladder cancer | urothelial cancer | circulating tumor cells | biomarker

ABSTRACT
The development of biomarkers to determine prognosis and predict response to therapy is an active area of research and represents an important part of the ongoing effort to individualize cancer care. Circulating tumor cells (CTCs) have demonstrated promise in several malignancies including prostate, breast, and colon cancer, and are being investigated prospectively as a correlative endpoint in clinical trials. Circulating tumor cells are also detectable in patients with advanced bladder cancer. The current review summarizes the recent technological advances in the detection and characterization of CTCs as well as their potential as a clinically useful biomarker in the management of patients with bladder cancer.
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