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Comparative Binding Studies of Titanium and Iron to Human Serum Transferrin

Author(s): M.H. Aarabi | S.M. Mirhashemi | M. Ani | A.A. Moshtaghie

Journal: Asian Journal of Biochemistry
ISSN 1815-9923

Volume: 6;
Issue: 2;
Start page: 191;
Date: 2011;
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Keywords: binding constant | Titanium | transferrin | iron

7 M-1 based on the Equilibrium dialysis technique. The binding of both metals to apo-htf appears to be pH dependent, changing with both increase and decrease pH. Titration studies demonstrate that transferrin specifically binds two moles Ti(IV) as complex with citrate per mol protein. spectrophotometery technique indicated that Ti(IV) ions cause a 13% reduction in binding of Fe(III) to transferrin. These results show that titanium competes with iron in binding to apo-htf. Although, the binding sites for these two ions seem to be similar, the binding of iron to apo-htf seems tighter.]]>
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