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Comparative Bioactivity Study of 45S5 and 58S Bioglasses in Organic and Inorganic Environment

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Author(s): G. Theodorou | O. M. Goudouri | E. Kontonasaki | X. Chatzistavrou | L. Papadopoulou | N. Kantiranis | K. M. Paraskevopoulos

Journal: Bioceramics Development and Applications
ISSN 2090-5017

Volume: 1;
Start page: 4 pages;
Date: 2011;
Original page

Keywords: bioactive glass | renewal | FTIR | SEM | SBF | DMEM | bioactivity

ABSTRACT
Melt derived bioactive glasses and sol-gel derived glasses have been extensively investigated and are reported to be bioactive. Investigation of the bioactivity was conducted in different media, like conventional Simulated Body Fluid (c-SBF), Dulbecco's Modified Eagle's Medium (DMEM) and Tris buffer solution. The aim of this work is to investigate and evaluate the in vitro bioactivity assessment of two commonly used bioactive glasses- 45S5 and 58S-soaked in DMEM and c-SBF, in order to compare the biological response of both glasses in organic and inorganic environments. For the samples immersed in c-SBF, the onset of apatite formation on the surface of 45S5 grains was slightly delayed in comparison to 58S. After 3 days in DMEM 58S powders revealed the formation of a crystalline HCAp phase on the surface of all grains in contrary to 45S5, where a sparsely developed amorphous apatite phase was developed.
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