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Comparative effect of diclofenac sodium and dexamethasone on incisional wound healing in dogs

Author(s): Adamu Abdul Abubakar | John Adebayo Maiye | Abubakar Sadiq Yakubu | Bashir Saidu | Umar Adamu | Sadiku Mohammed Sahabi

Journal: Scientific Journal of Veterinary Advances
ISSN 2322-1879

Volume: 1;
Issue: 4;
Start page: 94;
Date: 2012;
Original page

Keywords: Dexamethasone | Diclofenac sodium | Incisional wound | Histopathology | Healing interval

The study was carried out to compare and evaluate the effect of diclofenac sodium, a non-steroidal anti-inflammatory drug (NSAID) and dexamethasone, a steroidal, anti-inflammatory drug on incisional wound healing in dogs. Fifteen (15) clinically healthy, mixed sex, intact Nigerian local dogs free of dermatological lesion with mean age of 14.97±3.7 months (Mean ± SD) and mean body weight of 10.73± 2.6kg (Mean ± SD) were used for the study. The dogs were randomly divided into three treatment groups: A, B and C comprising of five dogs per group. A caudal mid-ventral laparotomy skin incision was made to create surgical wounds. Immediately after anesthetic recovery, 7.5% diclofenac sodium injection intramuscularly at standard clinical therapeutic dose rate of 2.5mg kg-1 was administered to group A for three day, 2.5% dexamethasone injection intramuscularly at standard clinical therapeutic dose rate of 0.25mg kg-1 was administered to the group B for three days. Group C were not treated with any anti-inflammatory medication. Subjectively, diclofenac sodium group shows shorter healing interval compare to dexamethasone group (P