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Comparative studies on Potential and Efficient Ayurvedic Drug for Alzheimer’s Disease

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Author(s): Naveen P | Shafna Asmy V.S. | Subhashini R | Thiagarajan B

Journal: Scholars' Research Journal
ISSN 0976-8459

Volume: 1;
Issue: 1;
Start page: 25;
Date: 2010;
Original page

Keywords: Alzheimer’s Disease | berberine | curcumin

ABSTRACT
Alzheimer’s disease is a neurodegenerative disease. The accumulation of amyloid-? peptide (A-?) derived from Amyloid precursor protein (APP) is a triggering event, leading to the pathological cascade of Alzheimer's disease (AD) and therefore the inhibition of amyloid-? production should be a rational therapeutic strategy in the prevention and treatment of Alzheimer's disease. Here, the comparative study of ayurvedic drugs for the treatment of Alzheimer’s disease is done. Ayurveda is a holistic approach to health that is designed to help people live long, healthy and well-balanced lives. The basic principle of Ayurveda is to prevent illness by maintaining balance in the body, mind and consciousness through proper drinking, diet and lifestyle, as well as herbal remedies. Berberine is a cholinesterase, quaternary plant alkaloid from the group of isoquinoline alkaloid. Curcumin (diferulomethane) is an identified yellow pigment and potent polyphenolic antioxidant. Both the ayurvedic compounds are subjected to docking and interaction studies to find the most suitable lead compound among the two, for the treatment of Alzheimer’s disease. The hydrogen bond interactions were analyzed after docking. For docking studies HEX4b tool was made use of and the interaction studies were analyzed using Swiss PDB Viewer.

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