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Comparative study of lipid profile in non-smokers, chronic smokers, and chronic smokers with acute

Author(s): Pampareddy B. Kollur | Satish B. Biradar | Sangappa V. Kashinakunti | Gurupadappa S. Kallaganada | ManjulaR | Jagadish B. Ingin

Journal: Electronic Physician
ISSN 2008-5842

Volume: 4;
Issue: 2;
Start page: 480;
Date: 2012;
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Keywords: Non-smokers | Chronic smokers | Acute myocardial infarction | Lipid profile

Introduction: Smoking is a major risk factor in the genesis of coronary atherosclerosis and development ofcoronary heart disease. Smoking may alter normal plasma lipoprotein levels. The present study was undertaken tocompare the lipid profile between non- smokers (Group A) and chronic smokers (Group B) and also betweenchronic smokers (Group B) and chronic smokers with acute myocardial infarction (AMI) (Group C).Methods: Thirty six apparently healthy non- smokers, 36 apparently healthy chronic smokers and 36 chronicsmokers with AMI were selected for the study. Fasting venous blood samples were collected; triglycerides (TG),total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) were measured. Low-density lipoproteincholesterol (LDL-C) and very low-density lipoprotein cholesterol (VLDL-C) were calculated by Friedwald’sformula.Results: The lipid profile was compared between Group A and Group B and also between Group B and Group C.There was a significant rise in TG, TC, LDL-C, VLDL-C and significant decrease in HDL-C in Group B comparedto Group A. There was a significant rise in TG, TC, LDL-C, VLDL-C and significant decrease in HDL-C in GroupC compared to Group B.Conclusion: Smoking increases the risk of atherosis and smoking modulates the ischemic heart disease risk throughgene-environment interaction. Further studies are required to ascertain the gene environment interaction.
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