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Comparative in vitro Osmotic Stability of Three Human Erythrocyte Genotypes in the Presence of Quinine and Chloroquine Phosphate

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Author(s): P.C. Chikezie

Journal: Asian Journal of Biochemistry
ISSN 1815-9923

Volume: 6;
Issue: 1;
Start page: 55;
Date: 2011;
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Keywords: P. falciparum | haemolysis | schizontocide | 8-aminoquinoline | Malaria

ABSTRACT
in vitro study was to ascertain the tendency of two quinoline (quinine and chloroquine phosphate) drugs to interfere with osmotic stability of three human erythrocyte genotypes, namely, HbAA, HbAS and HbSS. Spectrophotometric method was used for determination of the capacity of the erythrocyte genotypes to withstand osmotic stress in the presence of separate increasing concentrations (0.2, 0.4, 0.6 and 0.8 mg%) of the two antimalarials. The Mean Corpuscular Fragility (MCF) index of the three genotypes was in the order: HbAA
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