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Comparison of efficacy and tolerability of different brands of amlodipine in patients with mild to moderate hypertension

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Author(s): Molouk Hadjibabaie | Seyed Hamid Khoee | Ebrahim Nematipoor | Kheirollah Gholami | Afsaneh Fatahian | Zahra Jahangard

Journal: Journal of Pharmaceutical Care
ISSN 2322-4630

Volume: 1;
Issue: 2;
Start page: 41;
Date: 2013;
Original page

ABSTRACT
Background: The efficacy of amlodipine, a calcium channel blocker, in treating systemic hypertension is well established but the most efficacious brand of this drug is still uncertain. The cost of different brands of amlodipine is tremendously different which may affect decision-making in hypertension treatment. The purpose of this study was to compare the efficacy and safety of different brands of amlodipine (Amlodipine, Amlopress, and Norvasc) in the treatment of hypertension in adult patients. Methods: This was a double-blind, randomized, three-sequence crossover study. Ambulatory patients with hypertension who had the inclusion criteria were enrolled. Patients were randomized and entered into three groups to receive either brand of amlodipine in a crossover method. After every four weeks of treatment completed, the other brand of drug was prescribed. The total period of the study was 12 weeks for all three drugs including four weeks for each brand. Results: A total of 20 patients entered to the study, 15 completed the 12-week treatment schedule. The absolute reductions in seated and supine systolic blood pressure (SBP) and diastolic blood pressure (DBP) were similar with all three brands during the 4 weeks of treatment. Headache, malaise and weakness were the most common reported adverse effects (AE) with all three drugs. Generic amlodipine had the most AE as compared with other brands. These AE were mild and did not require withdrawal of the drug. Conclusion: There is no statistical difference in lowering blood pressure by three different brands of amlodipine thus everyone which has the lowest price can be the first choice. Keywords: Amlodipine, Amlopress, Norvasc, Hypertension
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