Author(s): Golnaz kazemi, Mohammad seifi and Hassan sheibani
Journal: Heterocyclic Letters
ISSN 2231-3087
Volume: 3;
Issue: 2;
Start page: 141;
Date: 2013;
Original page
Keywords: Guanidine hydrochloride | hydrazine hydrate | 3-phenacylidene-2-indolinone | spiro pyrimidine and spiro pyrazoline.
ABSTRACT
The condensation reaction of guanidine hydrochloride and hydrazine hydrate with 3- phenacylidene-2-indolinone, is extended to the formation of spiro[indole-3,4'-pyrimidin]-2(1H)- one and spiro[indol-3,3′-pyrazol]-2(1H)-one. These reactions occur in ethanol at reflux, in presence of sodium acetate. This method provides a new route to produce spiro pyrimidine and spiro pyrazoline in good yields.
Journal: Heterocyclic Letters
ISSN 2231-3087
Volume: 3;
Issue: 2;
Start page: 141;
Date: 2013;
Original page
Keywords: Guanidine hydrochloride | hydrazine hydrate | 3-phenacylidene-2-indolinone | spiro pyrimidine and spiro pyrazoline.
ABSTRACT
The condensation reaction of guanidine hydrochloride and hydrazine hydrate with 3- phenacylidene-2-indolinone, is extended to the formation of spiro[indole-3,4'-pyrimidin]-2(1H)- one and spiro[indol-3,3′-pyrazol]-2(1H)-one. These reactions occur in ethanol at reflux, in presence of sodium acetate. This method provides a new route to produce spiro pyrimidine and spiro pyrazoline in good yields.
