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Control of viral replication after cessation of HAART

Author(s): Van Gulck Ellen | Heyndrickx Leo | Bracke Lotte | Coppens Sandra | Florence Eric | Buvé Anne | Lewi Paul | Vanham Guido

Journal: AIDS Research and Therapy
ISSN 1742-6405

Volume: 8;
Issue: 1;
Start page: 6;
Date: 2011;
Original page

Abstract We describe two patients who did not experience a viral rebound after cessation of HAART which was initiated for progressive disease. CD4 T-cell count remained stable in one patient and progressively declined in the other, despite apparent viral control. We failed to identify any immune activation or genetic markers that could offer an explanation for this unusual "secondary controller" status. But their viruses are clearly less fit compared to viruses from rebounders.

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