Academic Journals Database
Disseminating quality controlled scientific knowledge

Convenient Cleavage Reaction of 1-Acylhydantoin to Amide

Author(s): Jun-ichi Yamaguchi | Kanako Nozaki Abe | Takao Narushima

Journal: International Journal of Organic Chemistry
ISSN 2161-4687

Volume: 03;
Issue: 03;
Start page: 194;
Date: 2013;
Original page

Keywords: Amides | Acylhydantoin | Chiral Auxiliaries | Cleavage | Lewis Acid

A cleavage reaction of 1-acylhydantoin by an amine in tetrahydrofuran at elevated temperature provided the corre-sponding amide and hydantoin in high yield. It was found that the addition of diethylaluminum chloride accelerated the cleavage reaction rate. The amide yield depended on the steric hindrance of the amine.
RPA Switzerland

Robotic Process Automation Switzerland


Tango Rapperswil
Tango Rapperswil