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Current concepts on anti-Phospholipase A2 receptor antibody in Idiopathic membranous nephropathy

Author(s): Ardalan Mohammad Reza

Journal: Journal of Renal Injury Prevention
ISSN 2345-2781

Volume: 2;
Issue: 2;
Start page: 71;
Date: 2013;
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Keywords: Membranous nephropathy | Nephrotic syndrome | Phospholipase A2 receptor | Anti-PLA2R antibody

Implication for health policy/practice/research/medical education:Phospholipase A2 receptor, is normally expressed in podocyte membrane. In fact the phospholipase A2 receptor (PLA2R) is a type I transmembrane glycoprotein related to the C-type animal lectin family such as the mannose receptor. PLA2R regulates a number of biological responses produced by secretory phospholipase A2s (sPLA2s). Determining anti-PLA2r serum levels in patients with nephrotic syndrome should designate a probable diagnosis of idiopathic membranous nephropathy and in patients in which idiopathic membranous nephropathy had a pathology confirmation may be a determining factor to exclude secondary forms of the disease. However, it is too early to abandon a kidney biopsy in patients with nephritic syndrome, and PLA2R as the newly introduced serologic study needs confirmations to finds its proper place in the field of clinical medicine.

Tango Rapperswil
Tango Rapperswil

RPA Switzerland

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