Academic Journals Database
Disseminating quality controlled scientific knowledge

DERIVADOS DEL 2-FURILETILENO INDUCEN LA MUERTE CELULAR PROGRAMADA EN CÉLULAS CHO DE MAMÍFERO

ADD TO MY LIST
 
Author(s): Hernández OC | Pimentel H | Llanes LL | Fernández S | Vazquez N | Perez GC

Journal: Electronic Journal of Biomedicine
ISSN 1697-090X

Volume: 2012;
Issue: 2;
Start page: 27;
Date: 2012;
Original page

Keywords: Bromine. Apoptosis. Furylethylene. DNA fragmentation. CHO. Mitotic index

ABSTRACT
Aim: to evaluate the morphological and physiological changes induced by the synthesized products G1 and UC245 and the apoptotic process using CHO cell culture. Material and Methods: the Ca2+ uptake, DNA fragmentation in 1,8% agarose gel electrophoresis, nuclear morphology and mitotic index were studied as evidence of programated death cell. Results: the cytosolic Ca2+ increase and DNA fragmentation observed in association with nuclear morphology changes were consistent as molecular mark of apoptosis induced by the 2-furylethylene derivatives studied. Conclusions: these two synthesized products could confirm an inductor effect on apoptotic mechanism of this cell line.
RPA Switzerland

RPA Switzerland

Robotic process automation

    

Tango Rapperswil
Tango Rapperswil