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Design and Development of Aceclofenac Fast Dissolving Tablets by Novel Hole Technology: A Novel Approach to Decrease the Disintegration Time and Increase the patient compliance

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Author(s): Upendra kulkarni and NG Raghavendra Rao

Journal: Drug Invention Today
ISSN 0975-7619

Volume: 3;
Issue: 6;
Start page: 91;
Date: 2011;
Original page

Keywords: Novel Fast Dissolving Tablets | Aceclofenac | Hole technology

ABSTRACT
Attempts were made to prepare Aceclofenac fast dissolving tablets by Novel Hole technology. When these fast dissolving tablets contacts with the saliva or gastro intestinal fluids, the saliva or fluid will enters the hole present in the tablet and immediate breaking of the tablet is going to takes place. This fast disintegration of tablets is also influenced by the formation of new absolute area. The prepared FDTs were subjected to various pre and post formulation studies. Its disintegration and dissolution rates were compared with the control formulation (without hole).In-vitro drug release of FDTs (AH) showed almost 99% of the drug was released at 4th minute, where as the control formulation A, shows the 99% drug release at 18th minute. Overall, this technique is novel and most useful for formulation into fast dissolving tablets.
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