Academic Journals Database
Disseminating quality controlled scientific knowledge

Design, Synthesis and Inhibitory Properties against Coxsackie B3/B6 of Some Novel Triazole Derivatives

ADD TO MY LIST
 
Author(s): Dongping Shao | Yanbing Yang | Fei Xue | Xianjin Luo | Reyila Wubulikasimu | Yuhuan Li | Rongmei Gao | Weidong Ye

Journal: International Journal of Organic Chemistry
ISSN 2161-4687

Volume: 03;
Issue: 01;
Start page: 41;
Date: 2013;
Original page

Keywords: 1 | 2 | 4-Triazole; Anti-Enterovirus; Coxsackie B Viruses

ABSTRACT
A series of 1,2,4-triazole derivatives were synthesized, and their abilities to inhibit the in vitro replication of Coxsackie B3/B6 were evaluated. Among the 1,2,4-triazole derivatives, compound 3 g displayed potent activity, with a high antiviral potency (IC50 = 1.71 μM (against CVB3), 1.43 μM (against CVB6)). The structures of all the new synthesized compounds were confirmed by 1H-NMR spectra, mass spectra and elemental analyses.
RPA Switzerland

Robotic Process Automation Switzerland

    

Tango Rapperswil
Tango Rapperswil