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Design, Synthesis and Inhibitory Properties against Coxsackie B3/B6 of Some Novel Triazole Derivatives

Author(s): Dongping Shao | Yanbing Yang | Fei Xue | Xianjin Luo | Reyila Wubulikasimu | Yuhuan Li | Rongmei Gao | Weidong Ye

Journal: International Journal of Organic Chemistry
ISSN 2161-4687

Volume: 03;
Issue: 01;
Start page: 41;
Date: 2013;
Original page

Keywords: 1 | 2 | 4-Triazole; Anti-Enterovirus; Coxsackie B Viruses

A series of 1,2,4-triazole derivatives were synthesized, and their abilities to inhibit the in vitro replication of Coxsackie B3/B6 were evaluated. Among the 1,2,4-triazole derivatives, compound 3 g displayed potent activity, with a high antiviral potency (IC50 = 1.71 μM (against CVB3), 1.43 μM (against CVB6)). The structures of all the new synthesized compounds were confirmed by 1H-NMR spectra, mass spectra and elemental analyses.
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