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Design, Synthesis and Pharmacological Evaluation of New Nonsteroidal Anti-Inflammatory Derived from 3-Aminobenzothieno[2,3-d]pyrimidines

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Author(s): Hend Nagah Hafez | Omar Khalid Al-Duaij | Abdel-Rhman Barakat A. El-Gazzar

Journal: International Journal of Organic Chemistry
ISSN 2161-4687

Volume: 03;
Issue: 02;
Start page: 110;
Date: 2013;
Original page

Keywords: Spirobenzothienopyrimidine | Triazolopyrimidine | Pyrazolopyrimidine | Analgesic | Anti-inflammatory | Ulcerogenic Effect

ABSTRACT
During the last few years, condensed thienopyrimidine derivatives have received considerable attention. The therapeutic importance of thienopyrimidines prompted us to synthesize some of spiro(benzothieno[2,3-d]pyrimidine-4-one) derivatives. Some of the novel benzothino-pyrimidine derivatives 3a, 9b, 10b, 11a, 11b, and 11c showed considerable potent anti-inflammatory and analgesic activity of superior G.I.T. safety profile in experimental rats in comparing to indomethacin and tramadol as reference drugs.
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