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Designing and synthesis of some b-lactam- quinazolone compounds for studying their activity against Escherichia coli and Bascillus subtilis

Author(s): Krishna Srivastava

Journal: International Journal of Systems Biology
ISSN 0975-2900

Volume: 1;
Issue: 2;
Start page: 15;
Date: 2009;
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Keywords: Quanzolone | ı-lactam | chloroacetyl chloride | triethylamine | antharanilic acid | 1 | 1-biphenyl-4 | 4-diamine

The synthesis of 2-Phenyl-3, 1-benzoxazine-4-one 1 have been obtained from the condensationof Antharanilic acid, acid chloride in pyridine.The compound 1 was then converted to its respectivequinazolone by condensing with benzidene or Hydrazina hydrates 2or 3. Compound 2 or 3 on heating witharomatic aldehyde gave 3-(p-Arylidenoamino diphenyl)/Arylideno-amino-2-phenyl-4-(3H) quinazolone 4 or 5.Interaction of 4 or 5with chloroacetyl chloride, anhydrous ZnCl2 undergoes cyclization to give 3-(p-Arylidenoamino diphenyl)/2-Phenyl-3-{4 (-aryl)-3-chloro azetidiones)]quinazolone 7a-e and 6a-e. The newcompounds have been screened for its bioevaluation against antimicrobial agents.
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