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Determination of Ketoconazole in tablets by using three different methods

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Author(s): BILJANA GJORGJESKA

Journal: European Medical, Health and Pharmaceutical Journal
ISSN 1804-5804

Volume: 4;
Start page: 8;
Date: 2012;
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Keywords: Assay | Ketoconazole | Tablets

ABSTRACT
Ketoconazole has been widely used as an antifungal drug that is formulated as tablets, cream and overthecounterketoconazole shampoo. The aim of this research was to study and to standardize an ultraviolet spectrophotometric (UVS)method, potentiometric and a high performance liquid chromatographic (HPLC) method for the determination ofketoconazole in commercially available Oromycosal® tablets. These three methods were compared and discussed withrespect to their sensitivity, selectivity and readyapplicabilityin routine analytical work. Absorption spectra andspectrophotometric determinations were carried out on the UVS spectrophotometer. Investigated concentrations were inrange from 0.003 to 0.02mg?dm3.The absorbance was measured at 224 nm. In potentiometric titrations glass and saturated (KCl) calomel electrode were used. HPLC analyses of ketoconazole were carried in the presence of econazoleas internal standard. It can be concluded that the described methods are simple, fast and reliable for determination ofketoconazole in pharmaceutical preparations. The preparation of the samples is easy, the excipients do not interfere inthe methods, so they can be used in routine quality control analysis.
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