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Development of non-Hodgkin’s lymphoma in a patient with primary biliary cirrhosis: A case report and review of the literature

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Author(s): Theoni Kanellopoulou | Alexandra Alexopoulou | Flora N. Kontopidou | Anna Filiotou

Journal: Annals of Gastroenterology
ISSN 1108-7471

Volume: 24;
Issue: 2;
Start page: 125;
Date: 2011;
Original page

ABSTRACT
Patients with autoimmune disorders seem to have an elevated risk of lymphoma, especially non-Hodgkin’s lymphoma (NHL). The increased risk has been attributed to the disturbance of immune function found in these patients or to the immunosuppressive therapy used to treat the autoimmune disorders. However, little information exists about the estimated baseline risk for lymphoma in patients with primary biliary cirrhosis (PBC). In this case report, we describe a female patient who developed nodal diffuse large B-cell lymphoma ten years following PBC diagnosis. Twenty five additional case reports (19 NHL and 4 Hodgkin’s disease (HD), 2 without data about NHL or Hodgkin’s disease) predominantly females were identified in the English literature. B-cell lymphoma was the most common NHL type reported but beyond that no clear predisposition for any specific lymphoma subtype was documented. PBC usually preceded lymphoma diagnosis. Fifteen cases had extranodal localization and the most common site was the liver.Keywords PBC, non-Hodgkin’s lymphoma, autoimmune disordersAnn Gastroenterol 2011; 24 (2): 125-128
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